Mat2dcorr - A Matlab Toolbox for 2D-COS

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mat2dcorr - a free toolbox for performing two-dimensional correlation (2D-COS) analysis with Matlab.


Mat2dcorr: Screenshot of the 2D control window (left) and the window 2D correlation analysis ... (right)

Since its introduction in 1989, two-dimensional correlation spectroscopy (2D-COS), sometimes referred to as two-dimensional correlation analysis, has become an invaluable analytical tool for spectroscopic characterization in various fields of application, including protein science, pharmacy, biomedical applications, and polymer or nanomaterial research. The technique of 2D-COS analysis was originally developed to study dynamic processes in which a spectroscopic probe is used to monitor the effect of an external perturbation on a given system. The system responds to the perturbation with characteristic changes that are monitored spectroscopically, e.g. by continuous acquisition of a spectral time series. The main purpose of 2D-COS investigations is to explore correlations that may exist between perturbation-induced spectral responses. In some situations, the 2D-COS analysis technique is useful not only to detect and visualize such correlations, but also to decipher the sequence of these spectral changes. Sources of perturbation may include changes in temperature, pH, pressure, concentration, or spatial coordinates when examining spatially heterogeneous samples. The 2D correlation concept has proven to be extremely useful in a wide variety of molecular spectroscopy applications based on IR, NIR, Raman, NMR, fluorescence and UV-visible spectroscopy.

An introduction into the history, mathematics and basic principles of 2D-COS can be found here:

Getting Started

Data Import & File Formats

Options of the mat2dcorr Toolbox

Related Publications and Web Links

Mat2dcorr: Illustration of Heterospectral 2D-COS (FTIR vs. Raman)


Jul 02, 2023: more details of the mat2dcorr Matlab toolbox will follow soon